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Epigenetic modifications include DNA methylation, histone modifications and non-coding RNA activity that can modulate genes, either by exacerbating or mitigating their expression[200]

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Their dysfunction is closely associated with neurodevelopmental disorders such as autism and schizophrenia ( The ventral pallidum (VP) receives GABAergic inputs from the nucleus accumbens and projects to the mediodorsal thalamic nucleus and prefrontal cortex, forming the “cortex-striatum-cortex” loop, which regulates motivated behavior and reward evaluation (25)

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